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KMID : 0366219680030010033
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Korean Journal of Hematology
1968 Volume.3 No. 1 p.33 ~ p.36
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A Case Report of Agranulocytosis Induced by Thiazina (Thiacetazone)
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이진오(李眞悟)/Jhin Oh Lee
이창홍(李昌弘)/이경자(李慶子)/강병순(姜炳淳)/Chang Hong Lee/Kyung Ja Lee/Byung Soon Kang
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Abstract
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A case of agranulocytosis induced by Thiazina has been clinically studied. A 18
year-old female patient was admitted to our depth with the complaints of high fever,
chill, sore throats and generalizes rash on the whole body surface. She has been
medicated Thiazina 3 tablets daily since March 1. '68 under the diagnosis of pulmonary
tuberculosis. Rash developed on the 20th of March followed 3 days later by high fever
with chill, and severe sore throat in addition to dysphagia. Cardinal physical findings on
admission were generalized rash, ulcerated-and-dirty coated tonsils, and the enlarged
liver. Initial W.S.C. count was 100/㎣, and its differential count was as followings:
Segmented neutrophil 4%; lymphocytes, 94%; immature cell 2%. Bone marrow findings
were compatible with agranulocytosis showing maturation arrest. The treatments were
chiefly aimed to the infection and sore throat
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KEYWORD
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